We prove that the automorphism group $\mathrm{Aut}(X)$ of an affine spherical variety $X$ acts transitively on the set of smooth points $X^{reg}.$ If every invertible regular function on $X$ is constant, we prove that $X$ is flexible, i.e., the subgroup of $\mathrm{Aut}(X)$ generated by all $\mathbb{G}_a$-subgroups acts transitively on $X^{reg}.$
